Folic acid restricts SARS-CoV-2 invasion by methylating ACE2

Folic acid restricts SARS-CoV-2 invasion by methylating ACE2

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The current COVID-19 pandemic is motivating us to elucidate the molecular mechanism of SARS-CoV-2 invasion and find methods for decreasing its transmissibility.We found that SARS-CoV-2 could increase the protein level of ACE2 in mice.Folic new balance 990 v3 red acid and 5-10-methylenetetrahydrofolate reductase (MTHFR) could promote the methylation of the ACE2 promoter and inhibit ACE2 expression.

Folic acid treatment decreased the binding ability of Spike protein, pseudovirus and inactivated authentic SARS-CoV-2 to host cells.Thus, folic acid treatment could decrease SARS-CoV-2 invasion and SARS-CoV-2-neutralizing antibody production in mice.These data suggest ranchy doodle that increased intake of folic acid may inhibit ACE2 expression and reduce the transmissibility of SARS-CoV-2.

Folic acid could play an important role in SARS-CoV-2 infection prevention and control.